Natalie Portman has signed on for her first major TV role. The Oscar winner is teaming up with “Friends” co-creator Marta Kauffman for a miniseries at HBO. Deadline reports that Portman will star in “We Are All Completely Beside Ourselves,” based on Karen Joy Fowler’s award-winning 2013 novel of the same name. The “Black Swan” actress has also signed on to executive produce.

Fowler’s book centers on Rosemary (Portman), a university student determined to make a fresh start at an out-of-state college. Rosemary moves away from her hometown in part to escape her reputation as “monkey girl,” a cruel nickname she was assigned on account of her sister Fern — a chimpanzee. From the time of both of their births, Rosemary and Fern were raised together for the purpose of an experiment by Rosemary’s father, a psychologist. But long before Rosemary heads away for college, Fern has been removed from the family home, and the repressed family never truly deals with the grief that comes with Fern’s absence.

Christopher Monger (“Temple Grandin”) will adapt the book. Gideon Raff (“Homeland”) is set to EP alongside Portman and Okay Goodnight’s Kauffman and Robbie Tollin. Hannah KS Canter, also of Okay Goodnight, will co-produce.

Portman has previously appeared in guest spots for “Sesame Street” and “Saturday Night Live,” and lent her voice to “The Simpsons,” but “We Are All Completely Besides Ourselves” marks her first starring role in the medium. She was last seen on the big screen in the feminist western “Jane Got a Gun.” “A Tale of Love and Darkness,” her feature directorial debut, opens August 19.

Kauffman’s Okay Goodnight is also developing an American adaptation of the successful Israeli TV family drama “Shtisel.” The new version of the show, titled “Emmis,” has been acquired by Amazon. Kauffman already has a hit show on a streaming service: she co-created Netflix’s “Grace and Frankie,” currently in the midst of wrapping production on its third season. The comedy stars Lily Tomlin and Jane Fonda.