With May’s up fronts on the horizon, networks are putting shows on the chopping block and calling up orders for new pilots left and right.

At ABC in particular, popular shows with female leads have been axed. The network has cancelled the Connie Britton country music drama “Nashville” after four seasons, and “Castle,” which co-starred Stana Katic and Nathan Fillion, after eight seasons. But the biggest bummer is that the Haley Atwell Marvel series “Agent Carter” has also been tossed in the can after two seasons. The show was a critical hit, but struggled to find an audience.

Thankfully ABC has ordered some replacement pilots and renewed many other popular shows with heavy female involvement. Its TGIT lineup is unchanged, with “Grey’s Anatomy,” “Scandal,” and “How To Get Away With Murder” all earning renewals. Disney-themed “Once Upon a Time” was renewed for Season 6, and freshman series “Quantico” and “The Catch” were both renewed for their second seasons.

And Atwell will soon play another Carter: she was quickly brought on to “Conviction,” a procedural that, according to The Hollywood Reporter, “tells the story of Carter Morrison (Atwell), the brilliant but ne’er-do-well daughter of a former president, who is blackmailed into taking a job as the head of Los Angeles’ newly created Conviction Integrity Unit.” Liz Friedman (“Jessica Jones”) penned the script. “The Following’s” Liz Friedlander will EP and direct the pilot.

The Sarah Dunn comedy, formerly known as “The Second Fattest Housewife in Westport” (thank goodness someone at the network thought well enough to rename this series), tells the story of a strong-willed mother raising her flawed family in a wealthy town filled with “perfect” wives and their “perfect” offspring. Dunn penned the script for ABC Studios.

“Downward Dog,” based on the web series of the same name, centers on a woman, Nan (“Fargo” breakout Allison Tolman), and her dog. As THR describes, “The twist is that it features a ‘Modern Family’-style confessional device — for the dog.”

“Imaginary Mary” is a live-action/CGI comedy “centering on a bachelorette (Jenna Elfman) whose life is turned upside down when she finally meets the love of her life — a divorced father with three kids. This triggers even more upheaval when the slightly unhinged imaginary friend she created as an only child suddenly reappears in her life to help her navigate the transition from single girl to a woman ready for a family.” It features Rachel Dratch as the voice of the imaginary friend.

ABC has also ordered “Still Star-Crossed,” which is a period drama that picks up where “Romeo and Juliet” left off. “It charts the treachery, palace intrigue, and ill-fated romances of the Montagues and Capulets in the wake of the young lovers’ tragic fate,” says THR. Based on the book by Melinda Taub, it was written by Heather Mitchell (“Grey’s Anatomy,” “Scandal”). Shonda Rhimes and Shondaland exec Betsy Beers produce. Rhimes will also add her first comedy, “Toast,” to the Shondaland lineup.

Over on CBS, the Halle Berry sci-fi drama “Extant” has been cancelled after two seasons, as was Melissa McCarthy’s star-making sitcom “Mike and Molly.” Tea Leoni’s “Madame Secretary” was renewed for Season 3. Freshman series “Supergirl” has been renewed for Season 2, but will be moving over to The CW to join fellow DC Comics series “The Flash” and “Arrow.”

New shows at CBS include a straight-to-series order of “American Gothic,” a murder-mystery drama from former “Good Wife” writer Corinne Brinkerhoff, THR reports.

Joining “Supergirl” on The CW will be “Jane the Virgin,” which has been renewed for Season 3, “Reign” will head into Season 4, and “Crazy Ex-Girlfriend” will see Season 2.

In the works at The CW is “No Tomorrow,” from the team behind “Jane the Virgin,” which is based on a Brazilian format and follows “a risk-averse, straight-arrow female procurement manager (Tori Anderson) at an Amazon-like distribution center,” as THR describes. “Jane’s” Corinne Brinkerhoff penned the script.

Also coming to The CW is a fresh take on the 2000 film “Frequency,” which THR details, “ In a twist from the feature, it centers on a female police detective (Peyton List) who in 2016 discovers she is able to speak via a ham radio with her estranged father (also a detective) who died in 1996. They forge a new relationship while working together on an unresolved murder case, but unintended consequences of the “butterfly effect” wreak havoc in the present day.”

Over at NBC, freshman series with female leads are still going strong, with renewals for Jaimie Alexander’s “Blindspot,” Jennifer Lopez’s “Shades of Blue,” and America Ferrera’s “Superstore.”

Fox will be saying goodbye to “Bones” after this upcoming 12th season, but “Empire” has been renewed for a third, “New Girl” for a sixth, and new hit series “Scream Queens” for a second.

Fox also has “Star” in the works from “Empire” co-creator Lee Daniels. The Atlanta-set drama revolves around three girls (newcomers Jude Demorest, Ryan Destiny, and Brittany O’Grady, discovered after a nationwide casting call) who come together to form a band. “‘Star’ details their rise to the top in a challenging business. While ‘Empire ’ is told from the point of view of music executives, ‘Star’ will be told from the perspective of the artist,” says THR.

Another big female-led series hitting Fox will be “Pitch,” which centers on a young female pitcher (Kylie Bunbury, “Under the Dome”) who defies the odds when she becomes the first woman to play in the major leagues. THR details, “In a first, Major League Baseball is partnering with Fox to produce the series, offering unparalleled access to its brand, logos, stadiums, and more.”

Also at Fox, Geena Davis will be starring in an adaptation of “The Exorcist,” and “It’s Always Sunny in Philadelphia” star Kaitlin Olson will star in “The Mick,” about “a hard-living, foul-mouthed woman who moves to affluent Greenwich, Conn., to raise the spoiled kids of her wealthy sister and brother-in-law, who have fled the country to avoid a federal indictment. She quickly learns what everyone else already knows: Other people’s children are awful,” the synopsis reads.

Losing great female-led series is hard, but hopefully the addition of these promising sounding pilots will make up for the losses.